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2003 Gruber Genetics Prize Citation

David Botstein, Professor of Genetics at Stanford University, has made numerous fundamental contributions to modern genetics.

Throughout his career he has been a powerhouse of innovation, and his concepts and strategies have repeatedly opened new avenues for modern genetic research.

His contributions cover much of the field of genetics, from the development of methods of mutagenesis of bacteria and yeast, to the analysis of the problems of bacteriophage assembly and of eukaryotic cell biology (such as the cytoskeleton and secretion), to the development of the basic principles of the application of genetic polymorphisms for the mapping of the human genome.

Most recently his strategy to use DNA-arrays to characterize normal cellular processes and disease-associated changes in these processes has paved the way towards genome-wide diagnostics.