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2014 Gruber Genetics Prize Citation

The Gruber Foundation proudly presents the 2014 Genetics Prize to Victor Ambros, David Baulcombe, and Gary Ruvkun for the discovery of small non-coding RNAs and for the demonstration of their central roles in the regulation of development and gene expression.

This research, which combined elegant genetics and molecular biology, demonstrated that a previously unknown class of RNAs (called microRNAs and small interfering RNAs) affected post transcriptional gene activity in nematodes and vertebrates (Ambros and Ruvkun) and in plants (Baulcombe). Their seminal findings led to an explosion in research that greatly increased our understanding of the control of such diverse processes as cell differentiation, developmental timing, cellular metabolism, cell death, and pathologies such as viral infection and cancer.