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2012 Gruber Neuroscience Prize Citation

The Gruber Foundation proudly presents the 2012 Neuroscience Prize to Lily and Yuh Nung Jan for their fundamental contributions to our understanding of both voltage-gated ion channels and neural development.

Working together, the Jans discovered that potassium channels were responsible for a distinctive behavioral phenotype and they were subsequently successful in cloning and extensively characterizing core members of three different ion channel families. In parallel investigations, they also made seminal discoveries regarding the development of neurons and glia, including key features of cell fate specification, asymmetric cell division and dendritic maturation.

The remarkable and continuing advances by the Jans have provided key insights into the development and function of the nervous system, and have inspired and guided both trainees and other investigators to pursue two important areas of research.