2019 Gruber Genetics Prize Citation

The Gruber Foundation proudly presents the 2019 Genetics Prize to Bert Vogelstein for his discoveries of new genetic pathways and processes contributing to cancer. He showed that malignant transformation of colorectal cancers results from the stepwise acquisition of mutations in oncogenes and tumor suppressor genes, thus elucidating the somatic evolution of cancer.  Using cutting edge technologies and approaches, he identified new genetic defects that alter cell signaling, promote cell growth, and compromise the integrity of DNA repair.  His work has advanced our understanding of cancer pathogenesis and led to the development of new diagnostic tests and targeted therapies for cancer.