2019 Gruber Neuroscience Prize

Joseph S. Takahashi, PhD, of the University of Texas Southwestern Medical Center is perhaps best known for his group’s discovery of the Clock gene in mice, which is a master regulator of circadian rhythms in mammals. Takahashi made groundbreaking discoveries in the neurobiology of circadian rhythms, including the isolation and cloning of the Clock gene. His use of innovative approaches to observe clock oscillations throughout the body in real time has revealed the broader impact of the circadian system in regulating the timing of cellular events in health and disease.