2019 Gruber Neuroscience Prize Citation

The Gruber Foundation proudly presents the 2019 Neuroscience Prize to Joseph S. Takahashi for his pioneering work on the molecular and genetic basis of circadian rhythms in mammals.

Takahashi has made groundbreaking discoveries in the neurobiology of circadian rhythms, including the isolation and cloning of the first mammalian circadian rhythm gene, known as the Clock gene.  Using elegant genetic approaches in mammals, his research has elucidated the networks of genes and proteins that interact to drive the circadian clock system and the feedback loops that govern their expression.  His use of innovative approaches to observe clock oscillations throughout the body in real time has revealed the broader impact of the circadian system in regulating the timing of cellular events in health and disease.