2021 Gruber Genetics Prize Citation

The Gruber Foundation proudly presents the 2021 Genetics Prize to Stuart Orkin for his pioneering discoveries of the genetic and molecular basis of common blood diseases and the gene regulatory mechanisms that govern blood cell development.  He elucidated the mechanism of regulation of the switch from fetal to adult hemoglobin, and reduced to practice the reactivation of fetal hemoglobin as a therapeutic strategy for sickle cell disease and the thalassemias.  Stuart Orkin’s science has beautifully illustrated the successful progression from fundamental genetics to mechanistic biology to therapeutic development and intervention, which can transform the lives of millions of patients in need.