The Gruber Foundation proudly presents the 2023 Genetics Prize to Allan Jacobson and Lynne Maquat for their discoveries and pioneering studies on the mRNA surveillance mechanism known as Nonsense Mediated mRNA Decay (NMD). NMD is a complex evolutionarily conserved pathway that plays an important role in genetics and the regulation of gene expression. Jacobson is being recognized for the genetic elucidation and analysis of the NMD pathway and related consequences of premature translation termination. Maquat is being recognized for elucidating the mechanisms and cellular importance of NMD and NMD factors in mammalian cells and human disease.
