2015 Gruber Neuroscience Prize Citation

The Gruber Foundation proudly presents the 2015 Neuroscience Prize to Carla Shatz and Michael Greenberg for their elucidation of the molecular mechanisms through which neural activity controls wiring and plasticity of the brain. 

Shatz’s pioneering studies showed that neural activity is needed for the refinement of connections in early brain development and revealed an unexpected role for immune signaling in neurons. 

Greenberg discovered that the “L-type” voltage-gated Ca2+ channel couples membrane excitability to gene transcription, elucidating in elegant detail the signaling pathways responsible.  

Together their ground-breaking studies have provided new insight into how neural circuit function regulates brain development and plasticity and how dysfunction can contribute to neuropsychiatric disorders such as autism and schizophrenia.